Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 10KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 10KG
Sigma Aldrich Fine Chemicals Biosciences Formic acid puriss. p.a., ACS reagent, reag. Ph. Eur., >=98% | 64-18-6 | MFCD00003297 | 500ML
Formic acid puriss. p.a., ACS reagent, reag. Ph. Eur., >=98% | Purity: >=98% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 500ML
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 g·mol-1 | C50H50ClN7O13 | 5 MG
CCT367766 formic is a heterobifunctional Cereblon-based PROTAC designed to induce targeted degradation of the pirin protein. It is intended for use as a chemical probe in mechanism-of-action studies and target validation, and is provided with analytical characterization data suitable for research applications.
- Cereblon-based PROTAC that degrades pirin.
- Third-generation heterobifunctional degrader for cellular target engagement studies.
- High reported purity of 98.1% for reliable experimental use.
- Characterized by LC-MS, HNMR, COA, and SDS documentation.
- Reported binding affinities: pirin Kd ≈55 nM, CRBN Kd ≈120 nM, IC50 (CRBN-DDB1) ≈490 nM.
- Available in small research quantities suitable for probe studies.
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 20kg | 480143866
Formic Acid, ACS Grade | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 20kg | 480143866
eMolecules 64-18-6 | Formic Acid | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 99.000 | OC=O | 1kg | 480142339
Formic Acid | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 99.000 | OC=O | 1kg | 480142339
Medchemexpress LLC BMT-124110 (formic) | 00-00-0 | MFCD34469994 | >98.0% | 369.46 g/mol | C21H27N3O3 | 5 MG
Small-molecule AAK1 inhibitor for laboratory research. It is a potent, selective AAK1 inhibitor (IC50 = 0.9 nM) with reported antinociceptive activity; it also inhibits BIKE (IC50 = 17 nM) and GAK (IC50 = 99 nM). Molecular formula C21H27N3O3; molecular weight 369.46 g/mol. Store powder at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month. Purity reported >98% (HPLC).
- Potent AAK1 inhibition (IC50 = 0.9 nM).
- Activity against BIKE and GAK (IC50s 17 nM and 99 nM).
- Suitable for biochemical and cellular kinase assays.
- Stable when stored as powder at -20°C.
- Supplied in milligram research quantities.
eMolecules Ambeed / Ammonium formate / 25g / 506390793 / A414767 / / 540-69-2 / MFCD00013103 / 63.056 / CH5NO2
Ambeed / Ammonium formate / 25g / 506390793 / A414767 / / 540-69-2 / MFCD00013103 / 63.056 / CH5NO2
Medchemexpress LLC DL-01 formic | 2964513-44-6 | 98.5% | 1144.30 g/mol | C56H73N9O15S | 1 MG
DL-01 formic is a drug-linker conjugate intended for research use in the synthesis of antibody-drug conjugates (ADCs). Supplied as a white to light yellow solid, it has high purity and requires ultra-low temperature storage to preserve stability.
- Drug-linker conjugate for antibody-drug conjugate (ADC) synthesis.
- White to light yellow solid physical form.
- Purity approximately 98.5%.
- Molecular weight 1,144.30 g/mol.
- CAS number 2964513-44-6.
- Stored at -80°C and protected from light under inert gas.
- Available in small milligram quantities for research use.
Medchemexpress LLC CBI1 formic | 461.40 | C16H21BrN4O3S2 | 10 MG
CBI1 formic is a covalent small-molecule inhibitor of BAX that selectively derivatizes the protein at cysteine 126 (C126), preventing BAX activation. Supplied for research use, structural and storage information is provided by the manufacturer.
- Covalent BAX inhibitor that derivatizes C126.
- Inhibits BAX activation induced by ligands or point mutations.
- Offered as a solid with sealed, moisture-free storage recommendations.
- Molecular formula C16H21BrN4O3S2; molecular weight 461.40.
- Available in small research pack sizes, including 10 mg.
- Intended for research use only; not for human or clinical use.
Sigma Aldrich Fine Chemicals Biosciences Formic acid, 64-18-6, MFCD00003297, 1 L
Linear Formula: HCOOH, Molecular Weight: 46.03, reagent grade, ≥95%.
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 MG
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor (IC50 of 90 nM) that binds to both GDP-loaded and active GNP states of KRAS. It exhibits broad-spectrum binding properties and is used for studying various RAS-driven tumors, such as pancreatic cancer.
- Potent KRAS (G12D) inhibitor with IC50 of 90 nM
- Binds to GDP-loaded and active GNP states of KRAS and KRAS (G12D)
- Exhibits broad-spectrum binding properties including for KRAS WT, G12C, Q61H, G13D, and HRAS
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells (IC50 = 70 nM)
- Non-toxic to non-KRAS-dependent HEK293 cells
- Significantly inhibits ERK phosphorylation in KRAS(G12C)-driven cell lineages
![Supply Solutions Sigma Aldrich - Formic acid puriss. p.a., for mass spectroscopy, 250ml .CAS Number: [000064-18-6]; Size: 250ml; CAS Number: 64-18-6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00114359-NC1256297.JPG-250.jpg)
Supply Solutions Sigma Aldrich - Formic acid puriss. p.a., for mass spectroscopy, 250ml .CAS Number: [000064-18-6]; Size: 250ml; CAS Number: 64-18-6
Sigma Aldrich - Formic acid puriss. p.a., for mass spectroscopy, 250ml .CAS Number: [000064-18-6]; Size: 250ml; CAS Number: 64-18-6
Medchemexpress LLC Slb1122168 formic | 2999629-17-1 | 99.9% | 403.56 | C23H37N3O3 | 10 MG
SLB1122168 formic is a research-stage small molecule that inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release. It has reported in vitro potency and is supplied for laboratory research with recommended storage and handling per the Safety Data Sheet.