Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 25KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 25KG
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 10KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 10KG
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 | 10 MG
CCT367766 formic is a potent, third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. It effectively depletes pirin protein expression at low concentrations and provides a potential chemical tool for studying this largely unexplored protein.
- Exhibits moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM.
- Demonstrates good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively.
- Depletes pirin protein in SK-OV-3 human ovarian cancer cells in a time-dependent manner.
- Rescues pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 1KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 1KG
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 5KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 5KG
Medchemexpress LLC SJ1008030 formic | 97.7% | 919.96 | 1 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2. This compound inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and is suitable for leukemia research.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM
- Can be used for leukemia research
- Purity of 97.7%
- Supplied as a light yellow to yellow solid
- Molecular formula C43H45N13O9S
Medchemexpress LLC BMT-124110 (formic) | 00-00-0 | MFCD34469994 | >98.0% | 369.46 g/mol | C21H27N3O3 | 5 MG
Small-molecule AAK1 inhibitor for laboratory research. It is a potent, selective AAK1 inhibitor (IC50 = 0.9 nM) with reported antinociceptive activity; it also inhibits BIKE (IC50 = 17 nM) and GAK (IC50 = 99 nM). Molecular formula C21H27N3O3; molecular weight 369.46 g/mol. Store powder at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month. Purity reported >98% (HPLC).
- Potent AAK1 inhibition (IC50 = 0.9 nM).
- Activity against BIKE and GAK (IC50s 17 nM and 99 nM).
- Suitable for biochemical and cellular kinase assays.
- Stable when stored as powder at -20°C.
- Supplied in milligram research quantities.
Medchemexpress LLC LCC-12 (formic) | 3029253-76-4 | 99.9% | 460.57 | 5 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II).
- Decreases the NAD(H) pool.
- Modulates inflammatory responses.
- Reduces inflammation in mouse models of bacterial and viral infections.
- Serves as a tool for investigating metabolic diseases.
- Affects cell plasticity.
- Affects epigenetic programming.
LifeSensors Ubiquitin Mass Spectrometry Kit
Mass spectrometry (MS) proteomics, especially when combined with TUBE technologies for protein enrichment, can be used in several innovative and impactful applications. Quantitatively profiling the ubiquitome can lead to the identification of ubiquitination sites on target proteins, and by extension unveiling the mechanisms of undiscovered E3 ligases with their substrates. MS can also inform small molecule drug discovery for these targets (e.g. PROTACs, molecular glues) by quantitatively reporting on how much target protein is degraded in the presence or absence of a drug candidate. This approach can also greatly aid the discovery and development of novel diagnostic biomarkers for challenging disease targets and development of clinically monitoring disease progression. All these applications require a simple, label-free, rapid ubiquitome approach. This kit is designed to address this for rapid yet reproducible proteomics. *The plate is designed for research use only.
Medchemexpress LLC Bisindolylmaleimide IX formic | 00-00-0 | 96.0% | C26H25N5O4S | 10MG
Ro 31-8220 formic is a small-molecule research reagent that acts as a potent, cell-permeable inhibitor of protein kinase C (PKC) and several other kinases. It is used in biochemical and cellular studies to probe PKC-dependent signaling, kinase selectivity, and downstream pathway effects such as JNK activation and c-Jun induction.
- Potent PKC inhibition with low-nanomolar IC50s.
- Inhibits multiple kinases for broad pathway interrogation.
- Cell-permeable for use in cellular assays.
- High purity solid with characteristic orange to red color.
- Stable when stored sealed at -20°C; in solvent can be stored at -80°C for extended periods.
- Available in small milligram pack sizes suitable for research use.