Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 g·mol-1 | C50H50ClN7O13 | 5 MG
CCT367766 formic is a heterobifunctional Cereblon-based PROTAC designed to induce targeted degradation of the pirin protein. It is intended for use as a chemical probe in mechanism-of-action studies and target validation, and is provided with analytical characterization data suitable for research applications.
- Cereblon-based PROTAC that degrades pirin.
- Third-generation heterobifunctional degrader for cellular target engagement studies.
- High reported purity of 98.1% for reliable experimental use.
- Characterized by LC-MS, HNMR, COA, and SDS documentation.
- Reported binding affinities: pirin Kd ≈55 nM, CRBN Kd ≈120 nM, IC50 (CRBN-DDB1) ≈490 nM.
- Available in small research quantities suitable for probe studies.
Medchemexpress LLC CBI1 formic | 461.40 | C16H21BrN4O3S2 | 10 MG
CBI1 formic is a covalent small-molecule inhibitor of BAX that selectively derivatizes the protein at cysteine 126 (C126), preventing BAX activation. Supplied for research use, structural and storage information is provided by the manufacturer.
- Covalent BAX inhibitor that derivatizes C126.
- Inhibits BAX activation induced by ligands or point mutations.
- Offered as a solid with sealed, moisture-free storage recommendations.
- Molecular formula C16H21BrN4O3S2; molecular weight 461.40.
- Available in small research pack sizes, including 10 mg.
- Intended for research use only; not for human or clinical use.
U.S. Pharmacopeia Formic Acid (1.2 mL/ampule; 3 ampules) | 64-18-6 | MFCD00003297
Formic Acid (1.2 mL/ampule; 3 ampules) | Mol Wt: 46.025 | 64-18-6 | MFCD00003297 |
Medchemexpress LLC Ivaltinostat (formic) | 98.3% | 473.56 | 1 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that features a hydroxamic acid moiety designed to bind zinc at the catalytic pocket. It inhibits deacetylation of histone H3 and tubulin, inducing p53 accumulation and promoting p53-dependent transactivation. This compound enhances the expression of MDM2 and p21 proteins, increases sensitivity of Gemcitabine-resistant cells to therapies, induces apoptosis, and demonstrates anti-tumour effects.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Promotes p53-dependent transactivation
- Enhances expression of MDM2 and p21 proteins
- Increases sensitivity of drug-resistant cells
- Induces apoptosis
- Exhibits anti-tumour effects
- Attenuates oxidative stress and inflammation
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 100g
Formic acid ammonium salt is an endogenous metabolite
Medchemexpress LLC SLB1122168 formic | C23H37N3O3 | 100 MG
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. It is intended for research use only and not for patient administration.
- Potent Spns2-mediated S1P release inhibitor
- Inhibitor with an IC50 of 94 nM
- Intended for research use
Medchemexpress LLC PKCiota-IN-2 formic | 2230055-52-2 | 99.0% | 402.36 | 25 MG
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. It also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively. This product is for research use only.
- Appearance: Solid
- Color: Light yellow to yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture and light).
- Solubility (in vitro): DMSO: 100 mg/mL (248.53 mM; requires ultrasonic).
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 | 10 MG
CCT367766 formic is a potent, third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. It effectively depletes pirin protein expression at low concentrations and provides a potential chemical tool for studying this largely unexplored protein.
- Exhibits moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM.
- Demonstrates good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively.
- Depletes pirin protein in SK-OV-3 human ovarian cancer cells in a time-dependent manner.
- Rescues pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells.
Medchemexpress LLC BMT-124110 (formic) | 00-00-0 | MFCD34469994 | >98.0% | 369.46 g/mol | C21H27N3O3 | 5 MG
Small-molecule AAK1 inhibitor for laboratory research. It is a potent, selective AAK1 inhibitor (IC50 = 0.9 nM) with reported antinociceptive activity; it also inhibits BIKE (IC50 = 17 nM) and GAK (IC50 = 99 nM). Molecular formula C21H27N3O3; molecular weight 369.46 g/mol. Store powder at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month. Purity reported >98% (HPLC).
- Potent AAK1 inhibition (IC50 = 0.9 nM).
- Activity against BIKE and GAK (IC50s 17 nM and 99 nM).
- Suitable for biochemical and cellular kinase assays.
- Stable when stored as powder at -20°C.
- Supplied in milligram research quantities.